As Virginia Hughes noted in a recent piece for National Geographic’s Phenomena blog, the most common depiction of a synapse (that communicating junction between two neurons) is pretty simple:
Signal molecules leave one neuron from that bulby thing, float across a gap, and are picked up by receptors on the other neuron. In this way, information is transmitted from cell to cell … and thinking is possible.
But thanks to a bunch of German scientists - we now have a much more complete and accurate picture. They’ve created the first scientifically accurate 3D model of a synaptic bouton (that bulby bit) complete with every protein and cytoskeletal element.
This effort has been made possible only by a collaboration of specialists in electron microscopy, super-resolution light microscopy (STED), mass spectrometry, and quantitative biochemistry.
says the press release. The model reveals a whole world of neuroscience waiting to be explored. Exciting stuff!
Credit: Benjamin G. Wilhelm, Sunit Mandad, Sven Truckenbrodt, Katharina Kröhnert, Christina Schäfer, Burkhard Rammner, Seong Joo Koo, Gala A. Claßen, Michael Krauss, Volker Haucke, Henning Urlaub, Silvio O. Rizzoli