anonymous said:

Hi I'm just chiming in on the horse abortion issue because I think a lot of people have the wrong idea. Pretty sure the anon who said it was inhumane was referencing a study on HUMANS because I can't find anything like that for horses. What's usually done late-stage is one or two injections of lutalyse and then larger quantities of saline. Its just an induced stillbirth and there are almost never adverse reactions from the mare. No more traumatic or dangerous than a normal stillbirth.

I also did my research. 

"TERMINATION OF UNWANTED PREGNANCY For a variety of reasons a veterinarian might be called to terminate an unwanted pregnancy. Twins and obvious fetal monsters may be clear indications, plus dam considerations which would make carrying a foal to term a dangerous option. Owners sometimes elect to terminate healthy pregnancies due to undesirable matings. It is valuable to review techniques of pregnancy termination since they depend on the endocrinology of pregnancy maintenance.

  1. Day 0 to 5- Essentially impossible, since the CL is refractory to prostaglandins. Saline lavage is ineffective since the embryo is still in the oviduct.
  2. Day 5 to 35-Single luteolytic dose of prostaglandin is effective. Mare should cycle back normally, and can be rebred.
  3. Day 35 to 160-After formation of the endometrial cups, response to a single dose of prostaglandins is variable, but repeated doses (sid or bid for 3-5 days) should be effective before day 70. Return to cyclicity is variable given due to presence of the endometrial cups. Estrous cycles may be irregular. As pregnancy advances, efficacy of prostaglandin will continue to decrease as the placenta becomes the primary source of progestogens.
  4. Day 160 to 310-Neither prostaglandins (lutalyse) nor corticosteroids will induce abortion during this period. Oxytocin does not become effective until after day 310.” - forum 

“Procedures become more complicated and dangerous as pregnancy progresses.Once the safety of the mare comes into question it is probably advisable to allow her to foal and either have the foal euthanized or find a willing adopter.” -site

“Severe localized clostridial infections associated with injection of LUTALYSE have been reported. In rare instances, such infections have resulted in death… Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract.” -site

I can’t find anything about what the anon was talking about either. Late term abortions has it’s risks, and since she was 60 days or less from foaling when I took her in, It was just best for her to have her foal. I included the part where it says it should not be used for things like problems with their respiratory system and reproductive tract, because (according to my ex-neighbor/her old owner) Millie had a “broken uterus” and he could never get her to carry a foal, so there’s probably some issue in there but as of right now I’m not positive about that. Hence, why he said she was “useless” and left her. But that’s why I was iffy about thinking she was pregnant, cause I knew she had a past of infertility. It’s kind of funny though, cause he left and she has a baby that he’s tried to get her to carry for YEARS. I never even considered aborting baby Houdini, cause I was prepared to take care of him no matter what. I love my babies.

Researchers discover fever’s origin

Fever is a response to inflammation, and is triggered by an onset of the signaling substance prostaglandin. Researchers at Linköping University can now see precisely where these substances are produced – a discovery that paves the way for smarter drugs.

When you take an aspirin, all production of prostaglandins in the body is suppressed. All symptoms of inflammation are eased simultaneously, including fever, pain and loss of appetite. But it might not always be desirable to get rid of all symptoms – there is a reason why they appear.

”Perhaps you want to inhibit loss of appetite but retain fever. In the case of serious infections, fever can be a good thing,” says David Engblom, senior lecturer in neurobiology at Linköping University.

Eleven years ago he had his first breakthrough as a researcher when he uncovered the mechanism behind the formation of prostaglandin Eduring fever. These signaling molecules cannot pass the blood-brain barrier, the purpose of which is to protect the brain from hazardous substances. Engblom showed that instead, they could be synthesised from two enzymes in the blood vessels on the inside of the brain, before moving to the hypothalamus, where the body’s thermostat is located.

Previous work from the research team described a very simple mechanism, but there was not yet proof that it was important in real life. The study to be published in The Journal of Neuroscience with David Engblom and his doctoral student Daniel Wilhelms as lead authors is based on tests with mice that lack the enzymes COX-2 and mPGES-1 in the brain’s blood vessels. When they were infected with bacterial toxins the fever did not appear, while other signs of inflammation were not affected.

”This shows that those prostaglandins which cause fever are formed in the blood-brain barrier – nowhere else. Now it will be interesting to investigate the other inflammation symptoms. Knowledge of this type can be useful when developing drugs that ease certain symptoms, but not all of them,” explains David Engblom.

For many years there has been debate as to where the fever signaling originates. Three alternative ideas have been proposed. Firstly, that it comes from prostaglandins circulating in the blood, secondly that it comes from immune cells in the brain, and thirdly Engblom’s theory, which stresses the importance of the brain’s blood vessels. The third proposal can now be considered confirmed.

Bright red lipstick makes me feel better when those prostaglandins are making me feel blah. 

Prostaglandins are the chemicals that loosen the uterine lining so it sheds, which is your period. They also are what cause things like nausea, diarrhea, and general flu-like feelings right before your period. 

Stem Cell Bodyguards: Insights into rare immune cells that keep blood stem cells in a youthful state may lead to better treatments

Hiding deep inside the bone marrow are special cells. They wait patiently for the hour of need, at which point these blood-forming stem cells can proliferate and differentiate into billions of mature blood immune cells to help the body cope with infection, for example, or extra red blood cells for low oxygen levels at high altitudes. Even in emergencies, however, the body keeps to a long-term plan: It maintains a reserve of undifferentiated stem cells for future needs and crises. A research team headed by Prof. Tsvee Lapidot of the Institute’s immunology Department recently discovered a new type of bodyguard that protects stem cells from over-differentiation. In a paper that appeared in Nature Immunology, they revealed how this rare, previously unknown sub-group of activated immune cells keeps the stem cells in the bone marrow “forever young.”

My body is producing a lot of prostaglandins right now. I’m in fucking pain. I don’t want babies right now so why must you shed my interior lining?!
Suggestion from article “lay a heating pad on low setting over your abdominal.” How about I fucking stab myself?!

Lipid levels during prenatal brain development impact autism

In a groundbreaking York University study, researchers have found that abnormal levels of lipid molecules in the brain can affect the interaction between two key neural pathways in early prenatal brain development, which can trigger autism. And, environmental causes such as exposure to chemicals in some cosmetics and common over-the-counter medication can affect the levels of these lipids, according to the researchers.

“We have found that the abnormal level of a lipid molecule called Prostaglandin E2 in the brain can affect the function of Wnt proteins. It is important because this can change the course of early embryonic development,” explains Professor Dorota Crawford in the Faculty of Health and a member of the York Autism Alliance Research Group.

This is the first time research shows evidence for cross-talk between PGE2 and Wnt signalling in neuronal stem cells, according to the peer reviewed study published at Cell Communication and Signaling.

Lead researcher and York U doctoral student Christine Wong adds, “Using real-time imaging microscopy, we determined that higher levels of PGE2 can change Wnt-dependent behaviour of neural stem cells by increasing cell migration or proliferation. As a result, this could affect how the brain is organized and wired.  Moreover, we found that an elevated level of PGE2 can increase expression of Wnt-regulated genes — Ctnnb1, Ptgs2, Ccnd1, and Mmp9. “Interestingly, all these genes have been previously implicated in various autism studies.”

Autism is considered to be the primary disorder of brain development with symptoms ranging from mild to severe and including repetitive behaviour, deficits in social interaction, and impaired language. It is four times more prevalent in boys than in girls and the incidence continues to rise. The US Center for Disease Control and Prevention (CDC) data from 2010 estimates that 1 in 68 children now has autism.

“The statistics are alarming. It’s 30 per cent higher than the previous estimate of 1 in 88 children, up from only two years earlier. Perhaps we can no longer attribute this rise in autism incidence to better diagnostic tools or awareness of autism,” notes Crawford. “It’s even more apparent from the recent literature that the environment might have a greater impact on vulnerable genes, particularly in pregnancy. Our study provides some molecular evidence that the environment likely disrupts certain events occurring in early brain development and contributes to autism.”

According to Crawford, genes don’t undergo significant changes in evolution, so even though genetic factors are the main cause, environmental factors such as insufficient dietary supplementations of fatty acids, exposures to infections, various chemicals or drugs can change gene expression and contribute to autism.

To everyone who has to deal with periods!

Alright, I know none of us like having to talk about this, but I have some information that might make your life a little easier.
Now I have been talking to my doctor, and some where along the lines we talked about periods. I didn’t enjoy having to talk about it. But I left that office with some extremely important information. First, here is the short version:
Take Advil 2-3 times a day (MAKE SURE ITS BEEN 8HOURS AFTER YOU LAST TOOK ADVIL BEFORE TAKING MORE) the two days before your period to make your cramps go away/lessen a ton.
What?! How does this work?! Well let me explain the long version to the best of my ability;
Advil lowers the release of a hormone called Prostaglandins. Prostaglandins cause swelling and pain, so you know where the injury is and such. Because you are hurt before you take Advil most of the time, the hormones are already released so it doesn’t stop cramps, it just lessens the pain a bit. With periods, you know they are coming, so taking Advil before your period stops lessens the amount of Prostaglandins released, making your cramps go away or lessen a lot.

Good luck friends! I hope this helps!

Breast milk is brain food
You are what you eat, the saying goes, and now a study conducted by researchers at UC Santa Barbara and the University of Pittsburgh suggests that the oft-repeated adage applies not just to physical health but to brain power as well.

In a paper published in the early online edition of the journal Prostaglandins, Leukotrienes and Essential Fatty Acids, the researchers compared the fatty acid profiles of breast milk from women in over two dozen countries with how well children from those same countries performed on academic tests.

Their findings show that the amount of omega-3 docosahexaenoic acid (DHA) in a mother’s milk — fats found primarily in certain fish, nuts and seeds — is the strongest predictor of test performance. It outweighs national income and the number of dollars spent per pupil in schools.

DHA alone accounted for about 20 percent of the differences in test scores among countries, the researchers found.

On the other hand, the amount of omega-6 fat in mother’s milk — fats that come from vegetable oils such as corn and soybean — predict lower test scores. When the amount of DHA and linoleic acid (LA) — the most common omega-6 fat — were considered together, they explained nearly half of the differences in test scores. In countries where mother’s diets contain more omega-6, the beneficial effects of DHA seem to be reduced.

Source and further reading:
http://www.universityofcalifornia.edu/news/breast-milk-brain-food

#cognitiveperformance   #breastmilk   #omega3fattyacids

http://click-to-read-mo.re/p/9n3Y/53e952d4

Scoperta l'origine della febbre

Scoperta l’origine della febbre

Che la febbre sia una risposta dell’organismo ad un processo infiammatorio è cosa nota. Meno chiaro e per anni oggetto di dibattito è stata invece l’origine del ‘segnale’ della febbre.

Le teorie in pista, fino ad oggi erano sostanzialmente tre: la febbre sarebbe originata dalla prostaglandine circolanti, oppure deriverebbe da cellule del sistema immunitario presenti nel sistema nervoso o infine…

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Sooo, only a few more hours till my wisdom tooth extraction. I have to take my antifibrinolytic and NSAI meds like, an hour before the appointment. I hope the avenue isn’t flooded. =[

Using everything as a learning experience, I found that tranexamic acid displaces plasmin (competitive antagonist), thus inhibiting fibrinolysis. And mefenamic acid is a nonsteroidal antiinflammatory drug, which is known for disrupting cyclooxygenase (like aspirin) in the formation of prostaglandins and TXA.

#pharma

Reosto preserve bone mass and bone microstructure.


Osteoporosis, a condition of excessive skeletal fragility, leads to bones that break simply, a significant unhealthiness nowadays with over 1.5 million fractures annually. Intensive analysis and testing on flavored ingredients by Himalaya has resulted in a very distinctive herbs mineral preparation, Reosto that slows bone loss and strengthens bone. It contains natural metal, atomic and nutriment D-like substances, helpful for bad people, similarly as those plagued by pathology. Plant hormones, gift in Reosto influence bone formation and minimize the chance of fracture caused by pathology.

Mechanism of action:
Reosto inhibit bone biological process (breaking down of bones). Reosto additionally negates the bone restorative effects of ductless gland hormones and prostaglandins. The drug is wealthy in elemental metal, which helps in higher bioavailability of the mineral. This enables the optimum quantity of mineral to be absorbed into the bone. Reosto stimulates bone formation and prevents the chance of osteoporotic fractures.

Soothing:- Due to its mitigating activity, Reosto mitigates swelling and agony connected with bone breaks and osteoporosis.

Evidence
  •  Osteoporosis (loss of bone thickness because of the diminishing of bone tissue, for example, frail osteoporosis and postmenopausal osteoporosis
  • Prolonged immobilization after various or complex cracks, or surgery for numerous breaks


Anti-inflammatory: owing to its medication action, Reosto alleviates swelling and pain related to bone fractures and pathology.

Benefits of Reosto

  •  It supports metal metabolism.
  •  It helps build and maintain healthy bones.
  •  This drug provides a natural supply of simply as similarly metal and cholecarciferol.
  •  It supports the microstructure of the bone tissue.
  •  It helps to preserve bone mass and bone microstructure.
  •  This pill helps to keep up secretion balance.


Indications:
Senile pathology,Postmenopausal pathology,Immobilization following fracture. Reosto Ingredients (Per Tablet):

  •  Arjuna
  •  Guggul
  •  Ashvagandha
  •  Sida cordifolia
  •  Rasna
  •  Natural Calcium
  •  Shell oxide


Dosage:
Take two Tablets double daily when meals.

Storage:
store in a very cool and dry place, far from direct daylight, don’t refrigerate keep of the reach of kids


Order Himalaya herbal Ayurvedic medicine online in cheapest rate form Onlyherbalpills.com online store. You can get health related medicine like Diarex, Reosto, purchase v-gel online etc.

In contrast, the botanical versions contribute many of these nutrients. Botanicals not only relieve pain and boost the immune system. They also supply nutrients to balance the system. In other words, white willow bark and meadowsweet—by nature’s design—contain a biomolecular version of salicin, moderated by a variety of constituents to balance its effects. Subsequently, whole-plant salicin botanicals do not have a history of the negative side effects. Their molecular arrangements are synergistically oriented with a balance of constituents, which resonate with and stimulate our body’s immune system while slowing the conversion of prostaglandins and leucotrienes to gradually ease inflammation. Unlike aspirin, willow and meadowsweet actually promote a healthy stomach lining, rather than ca…
Now you can order MTP kit online without prescription

Mifeprex KIT is the main Food and Drug Administration (FDA)-endorsed early alternative for non-surgical fetus removal in the initial 49 days of pregnancy.

Activity:

Mifeprex is a pill that squares progesterone, a characteristically delivered hormone that readies the covering of the uterus for a treated egg and aides keep up pregnancy. Without progesterone the pregnancy can’t proceed and the coating of the uterus diminishes, breaks down and draining starts. Mifeprex is trailed by a prostaglandin, misoprostol, which causes the uterus to contract and aides finish the procedure.

Data:

Albeit cramping and draining are a normal piece of completion a pregnancy, once in a while, genuine and conceivably life-undermining dying, diseases, or different issues can happen after a premature delivery, surgical fetus removal, therapeutic fetus removal, or labor. Brief medicinal consideration is required in these circumstances. Genuine disease has brought about death in a little number of cases; in the greater part of these cases misoprostol was utilized within the vagina. There is no data that utilization of Mifeprex and misoprostol brought about these passings. On the off chance that you have any inquiries, concerns, or issues, or on the off chance that you are agonized over any symptoms or indications, you ought to contact your supplier.

Who Should Not Take Mifeprex?

Some ladies ought not take Mifeprex if:

  • it has been more than 49 days (7 weeks) since your last menstrual period started.
  • you have an IUD. It must be taken out before you take Mifeprex.
  • your supplier has let you know that you have a pregnancy outside the uterus (ectopic pregnancy).
  • you have issues with your adrenal organs (perpetual adrenal disappointment).
  • you take a drug to thin your blood.
  • you have a draining issue.
  • you take certain steroid prescriptions.
  • you can’t return for the following 2 visits.
  • you can’t undoubtedly get crisis medicinal help in the 2 weeks after.


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Cetyl myristoleate supports optimal joint function and mobility by serving as a joint lubricant, and surfactant. This fatty acid ester also enables to stimulate the release of immunoglobulin (a class of proteins that function as antibodies in the immune response) and specific prostaglandins (series 1 and 3), which makes cetyl myristoleate a potent anti-inflammatory agent. visit us http://blog.tasmanhealth.co.nz/cetyl-myristoleate-modern-day-joint-lubricator/ for more details!!

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