Oxygen Microparticle Injections

The microparticles consist of a single layer of lipids (fatty molecules) that surround a tiny pocket of oxygen gas, and are delivered in a liquid solution.  In a cover article in the June 27 issue of Science Translational Medicine, John Kheir, MD, of the Department of Cardiology at Boston Children’s Hospital, and colleagues report that an infusion of these microparticles into animals with low blood oxygen levels restored blood oxygen saturation to near-normal levels, within seconds. 

This can be lifesaving seconds, and has so much potential for emergency situations. And this is just the beginning of new applications for amazing ways to deliver medicine. 

24 October 2013

Slow Release

To treat brain cancer, doctors typically cut out tumours before zapping residual cancer cells with chemotherapy. Problem is, chemo drugs don’t easily cross the blood-brain barrier, necessitating high doses that cause severe side effects. Doctors can leave drug-infused wafers in the brain after surgery, but the compounds are quickly broken down. Another solution is to encase the drugs in biodegradable polymer microcapsules that can be injected into the brain. And researchers have now developed a technique called ‘electrojetting’ to make microcapsules of uniform shape and size, which is crucial for the time-controlled release of the drugs they contain. A solution containing drug, polymer and solvent is squeezed through an electrically charged nozzle to produce evenly sized spheres, which will gradually release the drugs. Pictured is a scanning electron micrograph of the drug-loaded microspheres (coloured grey) overlaid with CGIs of drug molecules (purple) and brain cancer cells (yellow).

Written by Daniel Cossins

Mohammad Reza Abidian
Pennsylvania State University, USA
Copyright Wiley-VCH
Published in Advanced Materials 25(33): 4555-4560

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ああ、ウランUが…。 #NoNUKE 〜”Fig.1 Distributions of U, Cs, and Ba in Cs ball (lower right, SEM image)” Uranium-Containing Glassy Aerosol Microparticles Emitted during Fukushima Daiichi Nuclear Accident Reached Tsukuba -Multiple X-ray analyses using synchrotron radiation X-ray microbeam- (Press Release) Release Date 08 Aug, 2014