Primary Porcine Trabecular Meshwork

This winning image from GE Healthcare’s IN Cell Image Competition of 2008/9 reveals the internal structure of a fluorescently-stained trabecular meshwork cell. The red linear structures are filaments of actin spread throughout the cell, while the green patches at their tips are focal adhesions. DNA has been stained in blue.

The trabecular meshwork is located around the base of the cornea, near the ciliary body, and functions to drain aqueous humor from the eye. Excessive aqueous humor production or reduction to the outflow of aqueous humor can lead to an increase in intraocular pressure, which is normally associated with glaucoma.

Image by Carmen Laethem, Aerie Pharmaceuticals Inc., Research Triangle Park, North Carolina, USA.

FIVE.

That is my favorite number.

I was born on September 5.

We joined UP Cells on July 5.

Most importantly, I have 5 fingers (well, technically just 4 because thumb is not counted).

—-

Dapat pala 5 lang din batchmates ko. Dapat mag-evict ng isa. JOKE. HAHAHA

—-

From Celsy with love :)

Actin Antibody Available In Imgenex Now

Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is the monomeric subunit of microfilaments, one of the three major components of the cytoskeleton, and of thin filaments which are part of the contractile apparatus in muscle cells. It is the most abundant protein in the typical eukaryotic cell, accounting for about 15% in some cell types.

The protein is highly conserved, and forms a huge variety of structure in cells in concert with a huge numbers of actin binding proteins. The actin filaments interact with myosin to produce a sliding effect, which is the basis of muscular contraction and many aspects of cell motility, including cytokinesis.

The individual subunits of actin are known as globular actin (G-actin) that assembles into long filamentous polymers called F-actin. Two parallel F-actin strands twist around each other in a helical formation, giving rise to microfilaments of the cytoskeleton. Microfilaments measure approximately 7 nm in diameter with a loop of the helix repeating every 37nm.

Each actin protomer binds one molecule of ATP and has one high affinity site for either calcium or magnesium ions, as well as several low affinity sites. It exists as a monomer in low salt concentrations, but filaments form rapidly as salt concentration rises, with the consequent hydrolysis of ATP. Actin from many sources forms a tight complex with deoxyribonuclease (DNase I) although the significance of this is still unknown.

The formation of this complex results in the inhibition of DNase I activity, and actin loses its ability to polymerise. It has been shown that an ATPase domain of actin shares similarity with ATPase domains of hexokinase and hsp70 proteins. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma.

The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. MreB, a major component of the bacterial cytoskeleton, exhibits high structural homology to its eukaryotic counterpart actin.

Further it has been suggested that members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.

Actin Antibody Available In Imgenex Now

major, filaments, cytoskeleton, mreb, microfilaments, actin, cell

via the-power-on http://bit.ly/1c5K3QB

Here’s a list of things I’m sure about for tomorrow:

Chemiosmosis

Electron transport chain

Calvin cycle (general properties: carbon fixation, reduction and sugar production, and regeneration of RuBP)

uhhh… Cell parts. (Endoplasmic reticulum makes up most of the cell’s internal surface area).

Macromolecules: Carbohydrates, Proteins and Nucleic Acids are polymers. Lipids are…. triglycerides and phospholipids mmmmhm.

Saturated & Unsaturated fatty acids

CYTOSKELETON: Microfilaments (protein: actin) Intermediate filaments (several different types of proteins) and Microtubules (tubulin.. derr)

But what kind of protein makes up flagella and cilia???? well.. flagella is made of flagellum. cilia are made of dyenin and kynesin. 

Today I spoke with an advisor in Marine Sci IDS major… interdisciplinary is my game. and he was so nice and connected me with an undergraduate advisor and even said he’d absolutely love to see me around. i also called my mom right after and she didn’t seem that excited but that’s O. K . i’m still pretty stoked ngl. :-) 

i’d get to take a lot of conservation classes and aquatic mammalian classes. i still need chem 1 & 2 plus basic math (maybe able to get out???) , statistics and bio 2. i dont need physiccssss!! ! !!  ! !  !  !! !  lalalala. im afrad of physics straight UpP. 

and i could maybe even minor in nonprofit management since that’s what i’d end up doing probably why i am i posting this on tumblr

is this info too like… explicit idk im so excited !! i also am definitelygoing to apply to the arctic study abraod blabla for the summer. i dont want to take an entire semester just yet… seems like more stress than happiness. humhumhum. 

Scientists uncover clues to ATP mystery and how cells work

(Phys.org) —Strong, thin fibers called microfilaments, or actin filaments, are present in the cytoplasm of almost every cell in the body. By growing and shrinking, actin filaments play a major role in cellular movement. Since these processes require large amounts of energy, actin filaments use a lot of ATP (adenosine triphosphate), a molecule that is often called the energy currency of the cell.

via Phys.org - latest science and technology news stories http://bit.ly/1vc8B0A

Pocket-Sized Surveillance Drone Can Fly Through Windows
UAV could end up in the hands of law enforcement

A new pocket-sized surveillance drone endorsed by the US Air Force which could ultimately end up in the hands of law enforcement can fly through open windows and reach other confined spaces.

The Extreme Access Pocket Flyer, developed by Massachusetts-based startup CyPhy Works, features a 360 degree high-resolution panoramic camera and is just 7 inches long when fully configured. The drone also features wireless communications relay technology and enjoys “virtually unlimited flight time” as a result of being tethered to a microfilament battery that provides power.

The company was recently awarded a contract by the US Air Force to develop a version of the drone to be used in search and rescue missions such as in collapsed buildings.

However, CyPhy Works CEO Helen Greiner envisages the project being expanded so that the drone will eventually be available to law enforcement authorities.

“The initial targeted users of the Pocket Flyer are Air Force Pararescuemen, Special Forces units, and Federal Emergency Management Agency teams,” reports Ars Technica. “But the company sees a much larger market long-term. “Just like a camera, the best drone is the one you have with you,” Greiner said in a prepared statement on the contract. “The market potential is one for every soldier, marine, police officer, SWAT team member, and many other jobs that expose people to danger.”

Although the Pocket Flyer is small enough to fly through open windows, it is by no means the smallest surveillance UAV currently in the works.

A number of drones modeled after insects, birds and other small mammals are already being readied for use by the military and law enforcement bodies.

As far back as the 1970s, the CIA attempted to develop a petrol powered “insectothopter” drone, while anti-war protesters in Washington DC complained that they were under surveillance by a fleet of dragonfly drones at an event in 2007.

http://www.infowars.com/pocket-sized-surveillance-drone-can-fly-through-windows/

The Extreme Access Pocket Flyer, developed by Massachusetts-based startup CyPhy Works, features a 360 degree high-resolution panoramic camera and is just 7 inches long when fully configured. The drone also features wireless communications relay technology and enjoys “virtually unlimited flight time” as a result of being tethered to a microfilament battery that provides power. The company was recently awarded a contract by the US Air Force to develop a version of the drone to be used in search and rescue missions such as in collapsed buildings. However, CyPhy Works CEO Helen Greiner envisages the project being expanded so that the drone will eventually be available to law enforcement authorities. “The initial targeted users of the Pocket Flyer are Air Force Pararescuemen, Special Forces units, and Federal Emergency Management Agency teams,” reports Ars Technica. “But the company sees a much larger market long-term. “Just like a camera, the best drone is the one you have with you,” Greiner said in a prepared statement on the contract. “The market potential is one for every soldier, marine, police officer, SWAT team member, and many other jobs that expose people to danger.”

Learning biology rn is more like talking to myself:
“Hey babe, do you like my cytoskeleton? It’s made of microtubules and microfilaments.” “Your mitochondria drive me crazeeeey. They make my cells breathe harder.”
“Nice cristae.”
😖 save me from myself somebody. I am never gonna pass this class. I just want to watch youtube, eat and sleep.

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