immunity

Immunity is the ability of the body to tolerate material that is indigenous to it and eliminate material that is foreign.

The success of the immune system depends on its ability to distinguish between host (self) and foreign (non-self) cells.

The body’s first line of defense against infectious agents, or pathogens, is our skin and mucous membranes.

If a pathogen breaks through these barriers, it encounters a series of nonspecific immune defenses, including specialized cells and chemicals that seek out, identify, and destroy the pathogen, regardless of its identity.

This general response is nearly identical for each pathogen, and even if the body is exposed to the same pathogen many times the response each time is the same (there is no immunologic memory).

If a pathogen evades non-specific defenses, the body mounts a specific acquired immune response tailored to each pathogen.

Acquired immunity is divided into two types based on how it is acquired by the host:

  • Active immunity is provided by a person’s own immune system. This type of immunity can come from exposure to a disease or from vaccination. Active immunity usually lasts for many years and often is permanent.
  • Passive immunity results when antibodies are transferred from one person or animal to another. The most common form of passive immunity occurs when a fetus receives antibodies from his or her parent across the placenta during pregnancy. Passive immunity disappears over time, usually within weeks or months.

Some childhood vaccinations (e.g., measles) are scheduled so that the vaccine is given at the time when passive immunity from maternal antibodies is waning.

vaccine is a preparation of a weakened or killed microbe, or portion of it, that when administered, stimulates an immune response against the pathogen but which itself is incapable of causing severe infection.

If the body encounters the real disease-causing pathogen in the future, the immune system will “remember” the pathogen and can respond quickly to launch an immune response to prevent severe illness.

Each vaccine provides immunity against a particular disease; therefore, a series of vaccinations is administered to children and adults to protect them from many vaccine-preventable diseases.

Some vaccines are combined into a single injection. For example, DTP vaccine combines vaccines against three diseases — diphtheria, tetanus, and pertussis.

There are three main types of vaccines:

Live attenuated vaccines usually only require one dose to provide life-long immunity, with the exception of oral polio vaccine, which requires multiple doses. Examples include:

  • Virus (e.g., oral polio vaccine [OPV], measles, yellow fever)
     
  • Bacteria  (e.g., Bacillus Calmette-Guérin (BCG) vaccine, which prevents TB)

Inactivated vaccine may be whole-cell (made of an entire bacterial or viral cell) or fractional (composed of only part of a cell). Fractional vaccines are either protein- or polysaccharide-based. Examples include:

Whole

Virus (e.g., inactivated polio vaccine [IPV])

Bacteria (e.g., whole-cell pertussis)

Fractional

Protein-based

  • Subunit (e.g., acellular pertussis)
  • Toxoid (e.g., diphtheria and tetanus)

Polysaccharide-based

  • Pure (e.g., meningococcal)
  • Conjugate (e.g., Haemophilus influenzae type b [Hib])

Pure polysaccharide vaccines are generally NOT effective in children under the age of two UNLESS they are coupled with a protein.

This coupling process is known as conjugation.

Inactivated vaccines are not as effective as live vaccines.

Multiple doses are required for full protection.

And because protection by these vaccines diminishes over time, booster doses are needed to maintain immunity.

Recombinant vaccines are produced by inserting genetic material from a disease-causing organism into a harmless cell, which replicates the proteins of the disease-causing organism. The proteins are then purified and used as vaccine. An example of this is:

  • Hepatitis B

Individuals who have been immunized serve as a protective barrier for other individuals who have not been immunized, provided that the number immunized has reached a certain level, usually 80% or higher. Reaching and maintaining that level, which varies by communicable disease, provides "herd immunity" to unimmunized individuals. Herd immunity is especially important with extremely contagious diseases such as measles. -This is all from my my GlobalHealthLearning Immunization Essentials Class
Immunity - {RP: Bookmans-Lavi}

Allen walked with eyes open and alert, watching the other figures that mulled through the street with acute attention. The knowledge that very few could be trusted was an ever-present prick at the back of his mind, but he plastered an acknowledging smile on his face whenever anyone passed.

He self-consciously tugged his left sleep down a little more, despite that his deformed arm was fully covered alreay, as a passing man glared, a more common response to his smiles than actually having them returned. It didn’t bother him so much though, more than used to it. If people didn’t give him dirty looks for having glimpsed his abomination of an arm, they glared just because they could, because people were paranoid. It was reasonable enough though, he supposed.

He tried not to look skittish as a group of soldiers marched by, some giving him a visual once-over as if accusing him of some sort of hidden crime they needed only drag out into the open and expose, before doing what they did best… further sew animosity and fear into the uninfected with their own overly harsh tactics of “containment”.

The albino male jogged up a few steps to the entryway of an apartment building. He counted the doors lining the halls as he walked before settling on the one he had been searching for, giving an announcing knock first before cracking the door open, glad to find only one person currently inhabited the room.

"Hey, Lavi," Allen greeted casually. "Busy?"

07 October 2014

Cancer-fighting Communication

Your immune system has two ways to protect you. Cells in the innate system take on all invaders in a generic fashion, whereas specialised cells in the adaptive system learn to recognise and eliminate otherwise evasive pathogens. Both strategies involve dendritic cells, one of which is pictured here in an artist’s rendering. Dendritic cells share information to coach the adaptive system’s cells about which pathogens or pathogen-infected cells to hunt and how to destroy them. This involves exchanging information parcels called exosomes. But there’s a problem: cancer cells can hijack these communications to weaken the immune response. Using computer models, researchers have revealed that exosome exchanges between cancer and immune cells create three different cancer states. The intermediate state, with a moderate cancer load and an immune system on high alert, could potentially provide a window for combination treatments involving alternate cycles of immune-boosting therapies and cancer-killing chemotherapy.

Written by Daniel Cossins

Image by Don Bliss and Sriram Subramaniam
National Cancer Institute
This image is in the public domain and can be freely reused
Research published in PNAS, September 2014

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anonymous asked:

Is herd immunity a thing? Can vaccinated people get sick?

Herd immunity exists and it is well documented. In fact, there is a brilliant animation created by the Harvard Medical School that explains this process.

Vaccinations help prime your body to fight off a specific infection. However, it usually takes a few weeks for your body to create a reserve of immune cells for when you next encounter the infection again. Therefore, if you were infected just before or after receiving the vaccine, you might still get sick because the vaccine did not have ample time to provide any protection.

A summary of how vaccines work is available through the CDC.