The Man who Saved 2 million babies

Mr. Harrison started donating in 1954 and after the first few donations it was discovered that his blood contained an unusually strong and persistent antibody called Rho(D) Immune Globulin. Rho(D) IG is given to Rh(D) negative mothers of unknown or Rh(D) positive babies during and after pregnancy to prevent the creation of antibodies to the blood of a Rh(D) positive child. This antigen sensitization and subsequent incompatibility phenomenon causes Rhesus disease, the commonest form of hemolytic disease of the newborn (HDN).

As blood plasma, in contrast to blood, can be donated as often as every 2–3 weeks, he was able to reach his 1000th donation in May 2011. This results in an average of one donation every three weeks during 57 years. Commenting his then record number:

His donations were estimated to have helped to save over 2.4 million babies with pregnant women being treated with his antibodies, including his own daughter Tracey.

random hemonc NOT in first aid

Cabot rings ==> mitotic spindle remnants; seen in lead poisoning and pernicious anemia

Pappenheimer bodies ==> abnormal iron inclusion bodies; seen in sideroblastic and hemolytic anemias, sickle cell anemia

Watch on benmapz.tumblr.com

LMWH vs Unfractionated Heparin mnemonic

Watch on mediclopaedia.com

The original video on injecting a “dying girl, with HIV virus”… 

is a bit misleading.

http://scienceblog.cancerresearchuk.org/2013/06/25/no-doctors-did-not-inject-hiv-into-a-dying-girl-to-treat-her-cancer/

This article talks about the misconceptions that have been floating around the internet due to a problem in translation.. (between medical knowledge and the everyday knowledge of people). 

One child surviving ‘incurable’ cancer is an amazing event, but there is a lot more work to be done to find out how best to use this new technology. At the moment it’s still highly experimental and expensive. It’s only being trialled in a very small number of patients, primarily to make sure it is safe, and so far we’ve seen that it doesn’t work for everyone.

In the case of the child whose cancer came back after treatment, the researchers found that her cancer cells had somehow stopped carrying the T cells’ target molecule. So it’s likely that other targets will need to be identified, to make the treatment more effective for more patients in the future.

It is still however, amazing that research like this was done and is showing potential for future cures. Always an exciting day in the world of medicine!

Mantle Cell

"around the fireplace, around the follicle is the mantle"

like CLL in terms of CD’s but u lose the 23 ==> “michael jordan falls off the mantle”

"there’s an 11 in M" so theres translocation of 11:14, which is BCL1 aka cycline D1

Average survival is 3 years, 14-11 = 3

Count to 4 ==> 1, 2, 3, 4 u are missing the 23 so u get 1(1) and (14)

"what’s micky mantle’s #? 7" 1 + 1 + 1 + 4 (11;14)

#j barone is the man

http://www.ministrysync.com/event/website/?m=964680

Please donate for my team for The Walk for Purple! If you do message me and you get a surprise :) Anything helps, even a penny. Thanks guys! 

http://www.ministrysync.com/event/website/?m=964680

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http://www.ministrysync.com/event/website/?m=964680

http://www.ministrysync.com/event/website/?m=964680

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Paroxysmal Nocturnal Hemoglobinuria

I’ve never seen a uworld explanation that has something underlined.

Hemolytic anemia + hypercoagulable state + pancytopenia
PIGA needed for GPI anchor which binds CD55 (DAF), and CD59 (protectin) both inhibit complement.
Loss of PIGA causes unregulated complement, which is underlying mechanism of hemolysis.
A complication of the hypercoagulable state is venous thrombosis in hepatic veins and cerebral veins.}

The words underlyined where deficiency of CD55 and CD59  is diagnostic of PNH.

WBC precursors

image

(Pathomma image)

Lymphoblast
Large cells
Immature (not much cytoplasm)
Nucleolus (punched-out area)

Can’t differentiate on microscopy between myeloblast and lymphoblast.
If lymphoblast, there will be tdt+, key marker
If myeloblast, there will be myeloperoxidase
     - chemical study to detect enzyme
     - view under microscope (Auer rod)

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