2

Two more peautiful parasite so-to-speak-comics. This time it’s for Leishmania major (Leishmaniosis) and Entamoeba histolytica (erm… amoebiasis/dysentery). I drew both for learning reasons, as well as this one about Trypanosoma brucei and cruzi: http://cirolana.tumblr.com/post/43476269827/trypanosoma-brucei-and-cruzi-those-parasites-with and this one about general molecular parasitology aspects: http://cirolana.tumblr.com/post/43343364097/last-winter-i-learned-a-lot-about-parasitology

Gut-Eating Amoeba Caught In Action

A gut-eating amoeba (green) nibbles on a live human cell (purple) under the microscope. The parasite chews on the cell before killing and discarding it.

This nasty gut-eating amoeba can wreak havoc in your intestinal tract and cause a dreadful case of food poisoning that may last months or years. Now scientists have figured out how this amoeba makes us sick. Its tactics are more nefarious than we thought.

The single-cell animal bites off tiny chunks of intestine, chews on them for a while and then spits them out. That’s right, folks, the little parasites — called Entamoeba histolytica — don’t even have the courtesy to kill your cells before they take a bite. They don’t even digest the parts they eat.

Credit: Michaeleen Doucleff/NPR

Entamoeba histolytica cyst.

Drug Found for Parasite that is Major Cause of Death Worldwide

Research by a collaborative group of scientists from UC San Diego School of Medicine, UC San Francisco and Wake Forest School of Medicine has led to identification of an existing drug that is effective against Entamoeba histolytica. This parasite causes amebic dysentery and liver abscesses and results in the death of more than 70,000 people worldwide each year.

Using a high-throughput screen for drugs developed by the research team, they discovered that auranofin – a drug approved by the US Food and Drug Administration 25 years ago for rheumatoid arthritis – is very effective in targeting an enzyme that protects amebae from oxygen attack (thus enhancing sensitivity of the amebae to reactive oxygen-mediated killing).

The results of the work, led by Sharon L. Reed, MD, professor in the UCSD Departments of Pathology and Medicine and James McKerrow, MD, PhD, professor of Pathology in the UCSF Sandler Center for Drug Discovery, will be published in the May 20, 2012 issue of Nature Medicine.

Entamoeba histolytica is a protozoan intestinal parasite that causes human amebiasis, the world’s fourth leading cause of death from protozoan parasites. It is listed by the National Institutes of Health as a category B priority biodefense pathogen.  Current treatment relies on metronidazole, which has adverse effects, and potential resistance to the drug is an increasing concern.

More here

Greetings from Paris.
I met alot of doctors and professors which specialise in Entamoeba and parasitology today.
I feel like such a little fish in a huge amoeba soup.

Also I should be the first to sequence Entamoeba histolytica using SMRT sequencing and therefore should be able to finally achieve an unfragmented reference genome. And basically every Doctor, professor and post doc in the Entamoeba field us waiting for this. Not much pressure right? But I’m so excited to be part of something that’s never being done before and should help a lot of scientists in further research.

I’m so fortunate to have access to this breakthrough method of sequencing as there’s only a handful of SMRT sequencing machines in the world and only three in Britain. Like wow, just wow.

Mi Oaxaca

Dolores abdominales, náuseas y pérdida de peso, síntomas de parasitosis

 

 

 

 

 

Oaxaca, Oaxaca, Lunes 29 de Septiembre, 2014 (Fuente: Comunicado).- Afecciones que van desde el dolor abdominal y diarrea hasta llegar a la neumonía son algunos de los daños causados por parásitos, como: amibas, Áscaris lumbricoide y Tenia (solitaria), que afectan  especialmente a niños dada su propensión a jugar con la tierra y llevarse objetos a la boca, explica el área médica del Instituto Mexicano del Seguro Social (IMSS).

La parasitosis es la infestación de diversos tipos de parásitos, los cuales pueden causar daños de acuerdo a su tipo o la agresión a la mucosa. Ésta puede ser de dos tipos: por helmintos y por protozoos. Los helmintos son gusanos como Áscaris lumbricoide y Tenia, mientras que del grupo de los protozoos están las amibas, Entamoeba histolytica y Giardia intestinali.

Al respecto el Epidemiólogo del Hospital General de Zona 1 del IMSS, Miguel Ángel Altuzar Figueroa, indica que ambas pueden presentarse en cualquier persona; sin embargo, es más común en los niños, puesto que son los que suelen llevarse objetos a la boca y frecuentemente no se lavan las manos antes de comer, provocando así que los huevecillos fecundados de parásitos, lleguen al aparato digestivo.

Una vez que el huevo llega al intestino delgado, éste se abre, las larvas atraviesan las paredes intestinales y viajan a través del torrente sanguíneo hasta llegar a los pulmones, pasando por el hígado, el corazón y el sistema respiratorio.

Así mismo Altuzar Figueroa refiere que la principal forma de contagio es beber o lavar frutas y verduras con agua contaminada, así como llevarse las manos a la boca después de haber estado en contacto con superficies contaminadas.

Los pequeños que están infectados suelen tener náuseas, espasmos abdominales, diarrea repentina, y en casos severos pérdida de peso y anemia. En algunos casos la enfermedad es asintomática.

Por lo que recomienda el epidemiólogo del IMSS la desparasitación de todos los miembros de la familia cuando menos dos veces al año. Para ello, se recomiendan utilizar un desparasitaste eficaz, sencillo, que ayude a eliminar del organismo todo tipo de parásitos intestinales como amibas, lombrices y otros bichos.

Noticias de Oaxaca vía oaxacadiaadia.com


Fuente http://mioaxaca.com/?p=7989

Text
Photo
Quote
Link
Chat
Audio
Video