Revealing the Inner Workings of a Molecular Motor
Read the full article Revealing the Inner Workings of a Molecular Motor at NeuroscienceNews.com.
In research published in the Journal of Cell Biology, scientists from the RIKEN Brain Science Institute in Japan have made important steps toward understanding how dynein—a “molecular motor”—walks along tube-like structures in the cell to move cellular cargo from the outer structures toward the cell body of neurons.
The research in in Journal of Cell Biology. (full access paywall)
Research: “A flipped ion pair at the dynein–microtubule interface is critical for dynein motility and ATPase activation” by Seiichi Uchimura, Takashi Fujii, Hiroko Takazaki, Rie Ayukawa, Yosuke Nishikawa, Itsushi Minoura, You Hachikubo, Genji Kurisu, Kazuo Sutoh, Takahide Kon, Keiichi Namba, and Etsuko Muto in Journal of Cell Biology. doi:10.1083/jcb.201407039 (http://dx.doi.org/10.1083/jcb.201407039)
Image: Schematic representation of the dynein-microtubule complex showing the structural elements likely to be involved in allosteric communication between the microtubule and the ATPase site in dynein. Image adapted from the RIKEN press release.