New strategy sees therapy 'stiffening' cancer cells and limiting mobility.

New strategy sees therapy ‘stiffening’ cancer cells and limiting mobility. Thoughts health innovators?

Existing cancer therapies are geared toward killing tumour cells, but Johns Hopkins researchers propose a different strategy, subtly hardening cancer cells to prevent them from invading new areas of the body. They devised a way of screening compounds for the desired effect and have identified a compound that shows promise in fighting pancreatic cancer. The study is published the Proceedings of…

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Multicellular Madnes

The single-celled amoeba Dictyostelium discoideum, commonly known as slime mould is unique in that part of its lifespan is multicellular, with many amoeba aggregating together and forming a motile ‘slug’ which moves directionally towards stimuli such as light. Once a suitable location is found, they will develop and differentiate into a fruiting body to distribute spores.

Don’t believe? Check out this video


So how do they do this? When food supply is low they emit pulses of cyclic Adenosine Monophosphate (cAMP), this is detected by other amoeba that respond by emitting their own pulses of cAMP and by moving towards the signal (chemotaxis)

Pictured is the various stages of the multicellular lifecycle.



キイロタマホコリカビ(学名:Dictyostelium discoideum)は細胞性粘菌の一種として知られるアメーバ状の単細胞生物だが、特異なライフサイクルをたどることで知られている。食糧がなくなると大勢が合体して1匹のナメクジのようになり、養分を探して移動し、最終的にはキノコのような形になって「子実体」を形成し、その先の胞子を飛ばし、その胞子が発芽してまた同じサイクルを初めから繰り返す。



- 粘菌といえば、日本人研究者・南方熊楠が有名だ。粘菌は森の中で比較的容易に見つけられるというが、そもそも粘菌がどういう色・形なのかを知らないから、その探し方がわからない。コケ(=蘚苔類)だけでなく地衣類にも興味がある自分にとって、(カビは別にしても)粘菌にはとても興味がある。ところで、南方の破天荒な人生はあまりに特異だが、ひとつの学問に異常なほど傾注したり、そもそも学習能力が高いことから、アスペルガー症候群かサバン症候群の様相が垣間見れるのだ。素晴しい日本の偉人だ。 (via カラパイア)


Weekly Lab Meeting with Prof. Wolfgang Nellen, master and PhD researchers.
I was reporting the DNA clonning, gene knock down and stress response experiments in Dictyostelium discoideum, an amoeba.
Dept. of Genetics, Universität Kassel, DEU