Art by Philippe Delaby

"So when the duke and his wife were come unto the king, by the means of great lords they were accorded both. The king liked and loved this lady well, and he made them great cheer out of measure, and desired to have lain by her. But she was a passing good woman, and would not assent unto the king."

- Sir Thomas Malory, Le Morte D’Arthur

Systemic delivery of siRNA down regulates brain prion protein and ameliorates neuropathology in prion disorder.

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Systemic delivery of siRNA down regulates brain prion protein and ameliorates neuropathology in prion disorder.

PLoS One. 2014;9(2):e88797 

Authors: Lehmann S, Relano-Gines A, Resina S, Brillaud E, Casanova D, Vincent C, Hamela C, Poupeau S, Laffont M, Gabelle A, Delaby C, Belondrade M, Arnaud JD, Alvarez MT, Maurel JC, Maurel P, Crozet C

Abstract
One of the main challenges for neurodegenerative disorders that are principally incurable is the development of new therapeutic strategies, which raises important medical, scientific and societal issues. Creutzfeldt-Jakob diseases are rare neurodegenerative fatal disorders which today remain incurable. The objective of this study was to evaluate the efficacy of the down-regulation of the prion protein (PrP) expression using siRNA delivered by, a water-in-oil microemulsion, as a therapeutic candidate in a preclinical study. After 12 days rectal mucosa administration of Aonys/PrP-siRNA in mice, we observed a decrease of about 28% of the brain PrP(C) level. The effect of Aonys/PrP-siRNA was then evaluated on prion infected mice. Several mice presented a delay in the incubation and survival time compared to the control groups and a significant impact was observed on astrocyte reaction and neuronal survival in the PrP-siRNA treated groups. These results suggest that a new therapeutic scheme based an innovative delivery system of PrP-siRNA can be envisioned in prion disorders.

PMID: 24551164 [PubMed - indexed for MEDLINE] http://dlvr.it/7HdrFx