Catharanthus roseus (Apocynaceæ), the Madagascar periwinkle, is the source of vincristine and vinblastine, which are used to treat leukæmia and Hodgkin’s lymphoma. It is now common in cultivation, but— as with so much of the unique flora of Madagascar— it is now endangered in the wild.
Terkadang kita lupa bahwa alam di sekitar kita jauh lebih indah daripada tempat lain yang harus ditempuh perjalanan berhari-hari lamanya. Dijepret dari sebuah sudut halaman kantor tercinta dengan ASUS Zenfone 5.
A new extract of the plant calendula officinalis (marigold) produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation
US National Library of Medicine
Plants have a long history of use in the treatment of cancer. Active principles of Angelica Gigas, Catharanthus roseus, Podophyllum peltatum, Podophyllum emodii, Taxus brevifolia, Ocrosia elliptica, and Campototheca acuminata have been used in the treatment of advanced stages of various malignancies in the clinical setting. Furthermore, many phytochemicals with different pharmacological properties have shown responses for the prevention or treatment of different tumors, e.g., flavones, flavanols, isoflavones, catechins, and taxanes. Numerous drugs are used in cancer chemotherapy but most exhibit cell toxicity and can induce genotoxic, carcinogenic and teratogenic effects in non-tumor cells. These side effects limit the use of chemotherapeutic agents despite their high efficacy in treating target malignant cells. Therefore, the search for alternative drugs that are both effective and non-toxic in the treatment of cancers is an important research line. In fact, increased efforts are being made to isolate bioactive products from medicinal plants for their possible utility in cancer treatment.
Flowers of the plant Calendula officinalis, commonly known as “Marigold”, are used in the West and in Asia for their anti-inflammatory properties.
Phytopharmacological studies of different calendula extracts have shown anti-viral activity, anti-HIV properties of therapeutic interest, and anti-genotoxic properties. In clinical studies, Calendula was highly efficacious in the prevention of acute dermatitis in cancer patients undergoing postoperative irradiation. Its cytotoxic effect on tumor cell lines in vitro and its anticancer efficacy in vivo was briefly outlined 20 yrs ago Chemical constituents of C. Officinalis include some triterpenes, triterpene oligoglycosides, and flavonol glycosides. The aim of the present study was to evaluate the in vitro cytotoxic anti-tumor and immunomodulatory activities of a novel extract of the plant Calendula Officinalis.