'Life is suffering and the cause of suffering is desire' - Buddhists say. But you know what, without desires there's still suffering, because there is simply nothing to do here except fulfilling desires. It's a fuel for our engine. What are you gonna do here without desires? Stare at the sky? I'm telling you, it's scary to be left without desires. You gotta convince yourself you're still wanting something, advertise some new thing to yourself and buy your own pack of lies. Otherwise you won't find the strength to move a muscle.
—  Irina Uriupina
I offer you peace. I offer you love. I offer you friendship. I see your beauty. I hear your need. I feel your feelings. My wisdom flows from the Highest Source. I salute that Source in you. Let us work together for unity and love.
—  Gandhi 
The Four Noble Truths : Life Means Suffering

To live means to suffer, because the human nature is not perfect and neither is the world we live in. During our lifetime, we inevitably have to endure physical suffering such as pain, sickness, injury, tiredness, old age, and eventually death; and we have to endure psychological suffering like sadness, fear, frustration, disappointment, and depression. Although there are different degrees of suffering and there are also positive experiences in life that we perceive as the opposite of suffering, such as ease, comfort and happiness, life in its totality is imperfect and incomplete, because our world is subject to impermanence. This means we are never able to keep permanently what we strive for, and just as happy moments pass by, we ourselves and our loved ones will pass away one day, too.